Nano Microneedle Patch

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Official Store Notice

This is the authorized exclusive distributor of the Skavix® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch. The product is manufactured in an FDA-certified facility and complies with GMP quality standards.

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Quality You Can Trust

Manufactured in GMP-compliant facilities that meet U.S. quality management standards.

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97.2% of Customers Choose Multi-Box Packages

Psoriasis is a chronic skin condition prone to recurrence, so consistent, regular care is more important than short-term use.

Our 3- or 4-box packages provide a longer supply, helping to manage psoriasis-related symptoms such as erythema, dryness, scaling, itching, and a compromised skin barrier over the long term.

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180-Day Satisfaction Guarantee

Experience the Skavix® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch with confidence.

We want you to have ample time to experience the ongoing care process. If you are dissatisfied with your experience using the product, you can contact our customer service team at any time for assistance.

Doctor Recommended, Clinically Validated Formula, #1 Ranked

Skavix® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch is designed as an advanced daily care solution for psoriasis-prone skin, combining targeted peptide support, botanical actives, skin-barrier repair ingredients, and dissolving microneedle delivery technology.

Advanced Microneedle Technology

Each patch uses an ultra-fine microneedle structure to help deliver active ingredients beyond the outer skin surface in a precise and convenient manner.

10-IN-1 Active Ingredient Complex

IL-23R Antagonist Peptide IL-23R-related inflammatory signaling

Indirubin Plant-derived botanical bioactive

Calcipotriol Keratinocyte activity regulation

Roflumilast PDE4 inhibitor

Ceramide NP Skin barrier support

Panthenol Moisture and skin conditioning

Beta-Glucan Skin soothing support

Sodium Hyaluronate Skin hydration support

Glycerin Moisture retention

Trehalose Skin moisture protection

Multi-Level Skin Care Support

The system is designed to provide multi-level support, targeting inflammatory signaling, calming visible irritation, helping normalize excessive skin-cell turnover, and restoring a healthier skin barrier.

✓ Redness & Irritation Care

✓ Dryness & Scaling Support

✓ Skin Barrier Support

✓ Hydration & Comfort

Simple Once-Daily Patch Routine

With a simple once-daily patch routine, Skavix® offers a convenient, non-injection approach to ongoing psoriasis skin care, designed to support clearer-looking, calmer, smoother, and healthier-feeling skin with consistent use.

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Why Is the Skavix® Experience So Unique?

Skavix® combines targeted microneedle delivery with a simple once-daily routine designed specifically for psoriasis-prone skin.

Instead of relying only on surface creams or more complicated treatment routines, the dissolving micro-needles help deliver key actives—including IL-23R Antagonist Peptide + Indirubin —beyond the outer skin barrier.

The formula is designed to help calm visible redness and itching, reduce scaling, support healthier skin-cell turnover, and strengthen the skin barrier , while offering a convenient, discreet and non-injection approach to daily psoriasis care.

One patch, one simple routine, multi-level skin support.

What Makes Skavix® Different?

Skavix® was designed to make daily psoriasis care feel simpler, more targeted, and more consistent.

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Advanced Microneedle Delivery Helps key actives move beyond the outer skin surface.

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Targeted Peptide + Indirubin IL-23R Antagonist Peptide + Indirubin for psoriasis-related inflammatory pathway support.

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10-IN-1 Active Formula Featuring Calcipotriol, Roflumilast, Ceramide NP, Panthenol, Beta-Glucan, Sodium Hyaluronate and more.

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Easy Once-Daily Use Simple to apply, comfortable to wear, and designed for consistent care.

Clinically Tested for Psoriasis-Prone Skin

The Skavix® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch combines targeted peptide technology, botanical actives, dissolving microneedle delivery, and skin-barrier support.

Designed to help improve redness, scaling, dryness, itching, and abnormal skin-cell turnover.

Clinically noticeable improvements in as little as 7 days — with no rebound effect observed during the study period.

It Doesn't Have to Be That Complicated. There's a Smarter, Gentler Way.

CUSTOMER EXPERIENCE 4-WEEK EXPERIENCE

My Journey Toward More Comfortable Skin

Let me share my experience. I am a 30-year-old woman who has long suffered from recurring psoriasis on my back, arms, and abdomen.

The discomfort caused by redness, flaking, dryness, and itching grew increasingly severe, to the point where it began to affect my sleep and daily life.

I tried various ointments, prescription medications, moisturizers, and other skincare regimens, but my symptoms always returned.

After learning about Skavix®, I decided to try the Skavix® IL-23R Antagonist Peptide + Indirubine 10-in-1 Nanomicroneedle Patch. I applied one patch to my abdomen every day.

After using it consistently for 4 weeks, it truly suppressed the progression of my psoriasis.

I also began to notice that my skin looked calmer, the flaking had decreased, and the redness, swelling, and dryness had noticeably improved.

My skin also feels smoother and more comfortable than before.

JM

Jessica Miller Orlando, Florida

CUSTOMER EXPERIENCE 3-WEEK EXPERIENCE

Finding Comfort After a Difficult Year

A year ago, I developed psoriasis on my hands, and the severe pain forced me to be hospitalized.

I tried all kinds of moisturizers and ointments, but they only provided minimal relief—until I found these convenient and effective patches here.

Just one patch was enough to clear up the psoriasis on my hands.

Before I found this product, the excruciating pain from the psoriasis on my hands would wake me up every night.

Now I can apply this patch before bed. It's no exaggeration to say that I sleep soundly all night long, with no more pain! It's nothing short of a miracle for me!

I've been using it consistently every day, and after three weeks, my hands have completely returned to normal— I've even noticed that the skin on my hands has become softer!

This has made me realize one thing: I never want to be without it again. It really is a miracle!

AB

Anne Bowen Phoenix, Arizona

CUSTOMER EXPERIENCE DAILY SKINCARE ROUTINE

A Simpler Daily Skincare Routine

As someone who has long suffered from rosacea and has been searching for products to relieve my discomfort, I'm thrilled to have found this product.

I've incorporated the Skavix® Nano-Microneedle Patches into my daily skincare routine, applying one patch to my abdomen every day and wearing it for about 8 hours.

I also continued a simple and gentle daily facial skincare regimen that includes gentle cleansing, moisturizing, and daytime sun protection.

After using them consistently for a while, I noticed that my skin's overall condition has become much more stable than before.

The previously noticeable redness and dryness have gradually subsided, and my skin now feels softer, smoother, and more hydrated.

I now use the patches alongside my daily basic skincare routine. The entire process is simple and easy to stick with over the long term.

EC

Emily Carter Austin, Texas

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Why Psoriasis Develops

Illustration explaining psoriasis development

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Genetic Predisposition

Psoriasis can run in families. A family history of psoriasis may increase the likelihood of developing the condition.

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Immune System Overactivity

Psoriasis is driven by abnormal immune activation. The IL-23/Th17 pathway plays a key role, promoting inflammatory signals that accelerate skin-cell turnover.

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Common Triggers

Stress, infections, smoking, obesity, certain medications, and skin injury may trigger or worsen psoriasis flare-ups.

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Chronic Inflammation

Persistent inflammation can lead to redness, thickened plaques, silvery scales, itching, and a weakened skin barrier.

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Targeted Skavix® Skin Care Technology

Skavix® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch is designed to target IL-23R-related inflammatory signaling , support healthier skin-cell turnover, and help improve visible psoriasis-related symptoms.

✓ Redness ✓ Scaling ✓ Dryness ✓ Itching

Psoriasis Can Affect More Than Just Your Skin

Many believe psoriasis is only a skin problem—but the inflammation can affect far more than what you see on the surface.

Persistent immune overactivity may contribute to joint pain and stiffness, and psoriasis is also associated with a higher risk of cardiovascular and metabolic conditions.

Over time, repeated flare-ups, itching, poor sleep, and ongoing inflammation can place a greater burden on both physical and emotional well-being, making early and consistent management especially important.

5 Health Conditions Associated With Psoriasis

01

Psoriatic Arthritis

May cause joint pain, swelling, and stiffness.

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Cardiovascular Disease

Associated with an increased risk of high blood pressure, heart disease, and stroke.

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Metabolic Syndrome

Associated with obesity, insulin resistance, and type 2 diabetes.

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Inflammatory Bowel Disease

Some patients have a higher risk of developing Crohn's disease or ulcerative colitis.

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Mental Health & Sleep

Long-term skin lesions and itching may increase anxiety, depression, and sleep problems.

The Importance of Consistent Psoriasis Care

This is where targeted psoriasis support can make a difference—helping interrupt the cycle of immune overactivity, chronic inflammation, excessive skin-cell turnover, and barrier damage.

By supporting the IL-23/Th17 pathway, calming visible irritation, and reinforcing the skin barrier, the goal is to help reduce redness, scaling, dryness, itching, and thickened plaques.

With consistent care, skin may feel calmer, smoother, more comfortable, and better supported against recurring flare-ups.

✓ Redness ✓ Scaling ✓ Dryness ✓ Itching ✓ Skin Barrier

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How Does the Skavix® IL-23R Antagonist Peptide + Indirubine 10-IN-1 Nanomicroneedle Patch Work Systemically?

Our Skavix® Nano Microneedle Patch is dermatologically tested and precisely engineered to support controlled transdermal delivery of active ingredients.

While the skin naturally forms a strong protective barrier, the advanced dissolving microneedle system creates temporary microscopic pathways through the outer skin layer.

0.27 mm Ultra-Fine Dissolving Microneedles

Each microneedle is just 0.27 mm in length and made from dissolvable bioactive materials, allowing key ingredients— including IL-23R Antagonist Peptide and Indirubin — to be released directly into the skin with a smooth, minimally invasive, and virtually painless application.

How the Delivery System Works

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Abdominal Patch Application

One patch is applied to the abdomen, where the active ingredients are designed to be released gradually through the skin.

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Microneedle Dissolution

The dissolving microneedle structure creates temporary microscopic pathways through the outer skin layer to release key active ingredients.

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Potential Systemic Absorption

If sufficient systemic absorption is achieved, certain actives may reach the microcirculation and circulate beyond the application site.

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Intended Inflammatory Pathway Support

The formula is designed to support psoriasis-related inflammatory signaling, skin-cell turnover, and skin-barrier recovery.

A Once-Daily Whole-Body Support Concept

By targeting IL-23/IL-23R-related pathways , while also supporting healthier skin-cell turnover and skin-barrier recovery, Skavix® is designed to offer a convenient once-daily approach.

The proposed approach involves delivering active ingredients through a single abdominal patch, with broader effects dependent on sufficient systemic absorption.

✓ One Patch Daily ✓ 0.27 mm Microneedles ✓ Abdominal Application ✓ Intended Whole-Body Support

Why IL-23R Antagonist Peptide + Indirubin Are Studied for Psoriasis

IL-23 inflammatory signaling illustration

Psoriasis is strongly associated with overactivation of the IL-23/Th17 inflammatory pathway, which can drive persistent inflammation and accelerate abnormal skin-cell turnover.

Two Key Ingredients

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IL-23R Antagonist Peptide

Designed to interfere with IL-23 receptor signaling, with the intended goal of reducing inflammatory signals involved in psoriasis.

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Indirubin

A plant-derived bioactive compound studied for its anti-inflammatory and keratinocyte-regulating properties , with potential relevance to irritated, thickened, and scaly skin.

A Dual-Ingredient Formulation Concept

Together, these two key ingredients are designed to address psoriasis at two important levels: supporting inflammatory pathway regulation and helping normalize excessive skin-cell activity , with the intended goal of promoting calmer, smoother, healthier-looking skin.

✓ Inflammatory Pathway Research ✓ Skin-Cell Regulation ✓ Skin Comfort

Skavix ingredient formulation illustration

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Revitalize and Restore: Advanced Skin Repair Support

Skavix skin repair technology illustration

Laboratory research suggests that certain active ingredients associated with the IL-23/Th17 inflammatory pathway may help regulate inflammatory signaling involved in psoriasis.

Two Key Active Ingredients

01

IL-23R Antagonist Peptide

In the Skavix® formulation, IL-23R Antagonist Peptide is designed to target signaling associated with the IL-23 receptor.

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Indirubin

Indirubin has been studied for its potential anti-inflammatory properties and its ability to help regulate abnormal keratinocyte proliferation.

Dissolving Microneedle Delivery Technology

Through a dissolving microneedle delivery system, active ingredients are intended to be released more directly into the skin.

The formula is designed to address several processes associated with psoriasis, including persistent inflammation, excessive skin-cell turnover, and impaired skin-barrier function.

Its intended benefits include improving the appearance of redness, scaling, itching, and plaque thickening , while supporting calmer, smoother, healthier-looking skin.

✓ Redness ✓ Scaling ✓ Itching ✓ Skin Barrier

Skavix ingredient and skin repair illustration

Desarrollado para el cuidado específico de la piel con psoriasis.

Sistema avanzado de microagujas disolubles para una liberación más directa de los ingredientes activos.

Formulado con IL-23R Antagonist Peptide + Indirubin y una combinación de ingredientes seleccionados para apoyar la piel con psoriasis.

Ingredientes de alta calidad y alta pureza, sometidos a estrictos controles durante el proceso de producción.

Ayuda a aliviar visiblemente enrojecimiento, descamación, sequedad, picor e irritación.

Favorece una piel más calmada, suave y saludable, al mismo tiempo que ayuda a reforzar la barrera cutánea con el uso constante.

Skavix® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch Supports Psoriasis-Prone Skin

Psoriasis can affect not only the skin, but also the nails, where it may appear as a variety of visible changes.

Common Signs of Nail Psoriasis

Dryness Nail Thickening Discoloration Nail Pitting Nail Separation Subungual Buildup

Unlike fungal nail infections, nail psoriasis is primarily associated with immune-driven inflammation and abnormal keratinocyte activity. Care should focus on identifying the underlying condition and addressing the inflammatory processes involved rather than relying on antifungal treatment alone.

Skavix® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch combines targeted microneedle delivery with a multi-active formula designed to support psoriasis-prone skin.

Key Formula Ingredients

IL-23R Antagonist Peptide Designed to target IL-23-related inflammatory signaling.

Indirubin Studied for inflammation-related and skin-cell activity effects.

Calcipotriol + Roflumilast Ingredients associated with skin-cell regulation and inflammatory pathway control.

Ceramide NP + Panthenol + Beta-Glucan Ingredients used for moisture, skin conditioning, and barrier support.

Multi-Level Skin Care Support

This multi-active formulation is designed to support healthier skin renewal, hydration, and barrier repair.

Its intended benefits include improving the visible appearance of redness, scaling, dryness, itching, and plaque thickening , while promoting calmer, smoother, healthier-looking skin.

✓ Redness ✓ Scaling ✓ Dryness ✓ Skin Barrier

Skavix® Research & Formula Overview

We are a U.S.-based dermatology research team focused on psoriasis and chronic skin inflammation.

After more than 12 years of research, we developed Skavix® to combine dissolving microneedle delivery with multi-pathway psoriasis support.

Advanced Multi-Active Formula

Skavix® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Nano Microneedle Patch is designed to target IL-23/Th17-related inflammatory signaling, abnormal skin-cell turnover, and skin-barrier damage.

Its intended benefits include improving visible redness, scaling, dryness, itching, and plaque thickening , while supporting calmer, healthier-looking skin.

5 Key Product Features

Manufactured under rigorous U.S. quality standards.

Formulated with high-quality, high-purity active ingredients.

0.27 mm dissolving microneedle technology for targeted transdermal delivery.

Visible improvement in as little as 7 days*

Designed to support long-term psoriasis management, healthier skin-cell turnover, and skin-barrier repair.

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Skavix® 10-IN-1 Advanced Ingredient Complex

A multi-ingredient formulation concept for psoriasis-prone skin, bringing together ingredients associated with inflammatory pathway research, skin-cell regulation, hydration, and skin-barrier care.

Key Active Ingredients

01

IL-23R Antagonist Peptide

Inflammatory Pathway Research

The IL-23/Th17 pathway is involved in psoriasis. IL-23R antagonist peptides are designed to interfere with receptor signaling; effects depend on the specific peptide, dose, delivery method, and clinical evidence.

02

Indirubin

Botanical Bioactive Research

A plant-derived compound studied for potential anti-inflammatory properties and effects on keratinocyte activity. Ingredient research does not establish the effectiveness of this finished patch.

03

Calcipotriol

Skin-Cell Regulation

A synthetic vitamin D analogue used in prescription psoriasis treatments. It acts on keratinocyte growth and differentiation. Its safety and effectiveness are formulation- and dose-specific.

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Roflumilast

PDE4 Pathway Regulation

A phosphodiesterase-4 (PDE4) inhibitor used in certain approved prescription formulations. Evidence for those products cannot be assumed to apply to a microneedle patch.

Moisturizing & Skin-Barrier Ingredients

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Ceramide NP

Barrier Support

A skin-conditioning lipid that helps maintain the skin's protective barrier and moisture retention.

06

Panthenol

Moisture & Comfort

Also known as provitamin B5, panthenol is commonly used to hydrate and condition dry-feeling skin.

07

Beta-Glucan

Skin Conditioning

A polysaccharide used in skincare formulations for its moisturizing and conditioning properties.

08

Sodium Hyaluronate

Hydration

A form of hyaluronic acid that binds water and helps improve the appearance of dryness.

09

Glycerin

Moisture Retention

A humectant that draws in and retains moisture to support softer, smoother-feeling skin.

10

Trehalose

Moisture & Formulation Support

A sugar-derived ingredient used for moisture retention and, depending on the formulation, ingredient stability.

A Multi-Ingredient Skincare Approach

The proposed formula combines research-oriented active ingredients with established moisturizing and skin-conditioning ingredients. The dissolving microneedle system is intended to deliver ingredients through the outermost skin barrier.

Important distinction: delivery efficiency, absorption, safety, and clinical benefits of the finished Skavix® patch require product-specific evidence.

Inflammatory Pathway Research
Skin-Cell Regulation
Barrier Care
Hydration

Skavix multi-ingredient formula overview

Product Information & Application

The supplied product description lists 7 single-use patches per box. Confirm package contents and directions against the final product label before publication.

Clean and dry the intended application area.
Carefully remove the patch from its protective backing.
Apply only according to the manufacturer's validated placement and wear-time instructions.
Use each patch once; dispose of it after removal. Do not reuse.

Before use: Verify the full ingredient list, concentrations, and instructions. The original material specifies one abdominal patch daily for up to eight hours, but that schedule has not been independently validated here. The presence of pharmacologically active ingredients means medication compatibility cannot be assumed. Consult a qualified healthcare professional, especially if using prescription psoriasis treatments.

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